BLZ945，953769-46-5，HPLC>98%

中文同义词: BLZ 945

CAS号: 953769-46-5

分子式: C20H22N4O3S

分子量: 398.47868

生物活性 BLZ945是一种具有口服活性的，**的选择性 CSF-1R抑制剂，IC50为1 nM，比其*接近的受体酪氨酸激酶同系物高出1000多倍的选择性。

体外研究 In bone marrow-derived macrophages (BMDMs), BLZ945 specifically inhibIT(http://www.maoyihang.com/sell/l_25/)s CSF-1-dependent proliferation with EC50 of 67nM, and decreases CSF-1R phosphorylation. BLZ945 blocks the reciprocal effects between macrophages and glioma cells on the survival, proliferation and/ or polarization of each other to promote tumorigenesis.

体内研究 In glioma-bearing mice, BLZ945 blocks tumor progression and significantly improves survival via CSF-1R inhibition. BLZ945 also inhibits orthotopic tumor growth of patient-derived proneural tumor spheres and cell lines in vivo. BLZ945 (200 mg/kg, p.o.) decreases the growth of malignant cells in both mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis and keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis.

 

 

***瀚香生物产品特别注意***

 

1、全国免运费。

 

2、如果是学校、科研单位或厂家(http://www.maoyihang.com/company/)小试，需要小包装(http://www.maoyihang.com/sell/l_12/)，几克几百克的也可以分装。

 

3、质优价廉，量大更多优惠。

 

4、本公司(http://www.maoyihang.com/company/)销售(http://www.maoyihang.com/sell/)的所有产品均属于原料(http://www.maoyihang.com/sell/l_9/)，仅面向具有相关资质企业(http://www.maoyihang.com/company/)或者单位销售，我公司提供的产品仅供科研、实验室用，不对个人销售，更不可以直接食用。

 

5、秉持“客户购买我们的产品就是收获一份价值，一份安心”的信念；竭诚提供优质产品，售后服务(http://www.maoyihang.com/sell/l_11/)100％。